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VE against COVID-19–associated hospitalization during the full surveillance period was 86% (95% confidence interval = 82%–88%) overall and 90% (95% CI = 87%–92%) among adults without immunocompromising conditions. Overall, 141 (11.8%) case-patients and 988 (52.1%) controls were fully vaccinated (defined as receipt of the second dose of Pfizer-BioNTech or Moderna mRNA COVID-19 vaccines ≥14 days before illness onset), with a median interval of 65 days (range = 14–166 days) after receipt of second dose.
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Among 3,089 hospitalized adults (including 1,194 COVID-19 case-patients and 1,895 non–COVID-19 control-patients), the median age was 59 years, 48.7% were female, and 21.1% had an immunocompromising condition. In an evaluation at 21 hospitals in 18 states, the duration of mRNA vaccine (Pfizer-BioNTech or Moderna) effectiveness (VE) against COVID-19–associated hospitalizations was assessed among adults aged ≥18 years. Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19–associated hospitalizations ( 1– 4) measured shortly after vaccination longer follow-up is needed to assess durability of protection. Patel, MD 1 IVY Network Investigators ( View author affiliations) View suggested citation Schrag, DPhil 1 Miwako Kobayashi, MD 1 Jennifer R. Hart, MA 2 Yuwei Zhu, MD 2 Meagan Stephenson, MPH 1 Stephanie J. Stubblefield, MD 2 Adrienne Baughman 2 Kelsey N. Exline, MD 23 Natasha Halasa, MD 2 James D. Chang, MD, PhD 20 Christopher Mallow, MD 21 Carolina Rivas 21 Hilary M. Wilson, MD 19 Alexandra June Gordon, MD 19 Nida Qadir, MD 20 Steven Y. ten Lohuis, ACNP-BC 17 Abhijit Duggal, MD 18 Jennifer G. Monto, MD 15 Akram Khan, MD 16 Catherine L. Gong, MD 11 Amira Mohamed, MD 11 Daniel J.
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Hager, MD, PhD 9 Arber Shehu, MD 9 Matthew E. Mohr, MD 4 Anne Zepeski, PharmD 4 Manjusha Gaglani, MBBS 5 ,6 Tresa McNeal, MD 5 Shekhar Ghamande, MD 5 Nathan I.